Publications

Super-Abiraterone Acetate

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Super-Abiraterone Acetate development program

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Publications

Investigations of the mechanism behind the rapid absorption of nano-amorphous abiraterone acetate

Orsolya Basa-Dénes, Tamás Solymosi, Zsolt Ötvös, Réka Angi, Andrea Ujhelyi, Tamás Jordán, Gábor Heltovics, Hristos Galvinas
//Eur  J Pharm Sci. 2019 Mar 1;129:79-86 DOI: 10.1016/j.ejps.2019.01.001. Epub 2019 Jan 2.

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Preparation, Pre-clinical and Clinical Evaluation of a Novel Rapidly Absorbed Celecoxib Formulation

Réka Angi, Tamás Solymosi, Nikolett Ersdosi, Tamás Jordán, Balázs Kárpáti, Orsolya Basa-Dénes, John McDermott,Chris Roe, Stuart Mair, Zsolt Ötvös, Hristos Glavinas // AAPS PharmSci Tech. 2019 Jan 25;20(2):90 DOI: 10.1208/s12249-018-1270-2

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Solubility Measurements at 296 and 310 K and Physicochemical Characterization of Abiraterone and Abiraterone Acetate

Tamás Solymosi, Ferenc Tóth, János Orosz, Orsolya Basa-Dénes, Réka Angi, Tamás Jordán, Zsolt Ötvös, Hristos Glavinas
// J. Chem. Eng. Data, 2018, 63 (12), pp 4453–4458 DOI: 10.1021/acs.jced.8b00566.

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Development of an abiraterone acetate formulation with improved oral bioavailability guided by absorption modeling based on in vitro dissolution and permeability measurements.

Tamás Solymosi, Zsolt Ötvös, Betti Ordasi, Tamás Jordán, Sándor Semsey, László Molnár, Soma Ránky, Genovéva Filipcsei, Gábor Heltovics, Hristos Glavinas //Int J Pharm. 2017 Sep 15;532(1):427-434.

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Novel formulation of abiraterone acetate might allow significant dose reduction and eliminates substantial positive food effect

Tamás Solymosi, Zsolt Ötvös, Réka Angi, Betti Ordasi, Tamás Jordán, László Molnár, John McDermott, Vanessa Zann, Ann Churc, Stuart Mair, Genovéva Filipcsei, Gábor Heltovics, Hristos Glavinas //Cancer Chemother Pharmacol. 2017 Aug 3.

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Sirolimus formulation with improved pharmacokinetic properties produced by a continuous flow method

Tamás Solymosi, Réka Angi, Orsolya Basa-Dénes, Soma Ránky , Zsolt Ötvös, Hristos Glavinas, Genovéva Filipcsei  and Gábor Heltovics //Eur J Pharm Biopharm. 2015 Aug;94:135-40.

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Novel Continuous flow technology for the development of nanostructured Aprepitant formulation with improved pharmacocinetics properties

Réka Angi, Tamás Solymosi, Zsolt Ötvös, Betti Ordasi, Hristos Glavinas, Genovéva Filipcsei, Gábor Heltovics and Ferenc Darvas //Eur J Pharm Biopharm. 2014 Apr;86(3):361-8.

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Flow chemistry for nanotechnology, Flow chemistry graduate textbook, Chapter 6, Vol.2.: Applications,  Ed. by Darvas, Ferenc / Hessel, Volker / Dorman, György, Walter de Gruyter, 2014, pp 161-187

Genovéva Filipcsei, Zsolt Ötvös, Réka Angi and Ferenc Darvas

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